E-ISSN 2475-0581
 

Original Article 


Effect of Sex on Treatment Compliance and Brain Activity Alterations in Patients with Schizophrenia: A Pilot Study

Feng Ji, Ranli Li, Xiaoyan Ma, Lina Wang, Gongying Li, Feng Jia, Ying Wang, Chuanjun Zhuo, Gao Si, Jingjing Zhu, Peiwei Shan.

Abstract
Objectives: Antipsychotic agents remain the primary treatment for schizophrenia. However, treatment compliance can influence the prognoses of patients. Previous studies have reported that sex can influence the side effect and compliance of antipsychotics. However, sex-related effects on treatment compliance and brain activity patterns remain to be investigated in schizophrenia. We conducted a pilot study to (1) investigate how sex may influence treatment compliance in patients with schizophrenia and to (2) characterize brain activity features associated with sex-specific differences in treatment compliance.
Methods: We enrolled 53 male and 45 female patients with schizophrenia in this pilot study. The Adherence Rating Scale (MARS) was adopted to evaluate the treatment compliance of patients, while global functional connectivity density (gFCD) was used to assess brain activity features. The positive and negative assessment scale (PANSS) was adopted to assess the psychotic symptoms.
Results: In this pilot study, male patients had significantly higher MARS scores (P<0.05) than female patients. In addition, when compared to female patients, male patients demonstrated increased gFCD in the prefrontal lobe, posterior parietal cortex, cingulate cortex, central anterior sulcus, and superior frontal gyrus, especially in the left hemisphere. However, both male and female patients demonstrated decreased gFCD when compared to the healthy controls (P<0.001, FEW corrected).
Conclusions: Despite the limitations of this pilot study, our findings suggest that male patients with schizophrenia have better treatment compliance and higher brain activity, primarily in the central executive network and dorsal attention network, as compared to females. These findings provide clues for further exploration of treatment compliance-related mechanisms in schizophrenia.

Key words: Schizophrenia, treatment compliance, antipsychotics, sex, gFCD, PANSS


 
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How to Cite this Article
Pubmed Style

Ji F, Li R, Ma X, Wang L, Li G, Jia F, Wang Y, Zhuo C, Si G, Zhu J, Shan P. Effect of Sex on Treatment Compliance and Brain Activity Alterations in Patients with Schizophrenia: A Pilot Study. Psychiatry and Clinical Psychopharmacology - PCP. 2020; 30(3): 214-221. doi:10.5455/PCP.20200223125521


Web Style

Ji F, Li R, Ma X, Wang L, Li G, Jia F, Wang Y, Zhuo C, Si G, Zhu J, Shan P. Effect of Sex on Treatment Compliance and Brain Activity Alterations in Patients with Schizophrenia: A Pilot Study. http://www.psychiatryandclinicalpsychopharmacology.org/?mno=88583 [Access: October 01, 2020]. doi:10.5455/PCP.20200223125521


AMA (American Medical Association) Style

Ji F, Li R, Ma X, Wang L, Li G, Jia F, Wang Y, Zhuo C, Si G, Zhu J, Shan P. Effect of Sex on Treatment Compliance and Brain Activity Alterations in Patients with Schizophrenia: A Pilot Study. Psychiatry and Clinical Psychopharmacology - PCP. 2020; 30(3): 214-221. doi:10.5455/PCP.20200223125521



Vancouver/ICMJE Style

Ji F, Li R, Ma X, Wang L, Li G, Jia F, Wang Y, Zhuo C, Si G, Zhu J, Shan P. Effect of Sex on Treatment Compliance and Brain Activity Alterations in Patients with Schizophrenia: A Pilot Study. Psychiatry and Clinical Psychopharmacology - PCP. (2020), [cited October 01, 2020]; 30(3): 214-221. doi:10.5455/PCP.20200223125521



Harvard Style

Ji, F., Li, . R., Ma, . X., Wang, . L., Li, . G., Jia, . F., Wang, . Y., Zhuo, . C., Si, . G., Zhu, . J. & Shan, . P. (2020) Effect of Sex on Treatment Compliance and Brain Activity Alterations in Patients with Schizophrenia: A Pilot Study. Psychiatry and Clinical Psychopharmacology - PCP, 30 (3), 214-221. doi:10.5455/PCP.20200223125521



Turabian Style

Ji, Feng, Ranli Li, Xiaoyan Ma, Lina Wang, Gongying Li, Feng Jia, Ying Wang, Chuanjun Zhuo, Gao Si, Jingjing Zhu, and Peiwei Shan. 2020. Effect of Sex on Treatment Compliance and Brain Activity Alterations in Patients with Schizophrenia: A Pilot Study. Psychiatry and Clinical Psychopharmacology, 30 (3), 214-221. doi:10.5455/PCP.20200223125521



Chicago Style

Ji, Feng, Ranli Li, Xiaoyan Ma, Lina Wang, Gongying Li, Feng Jia, Ying Wang, Chuanjun Zhuo, Gao Si, Jingjing Zhu, and Peiwei Shan. "Effect of Sex on Treatment Compliance and Brain Activity Alterations in Patients with Schizophrenia: A Pilot Study." Psychiatry and Clinical Psychopharmacology 30 (2020), 214-221. doi:10.5455/PCP.20200223125521



MLA (The Modern Language Association) Style

Ji, Feng, Ranli Li, Xiaoyan Ma, Lina Wang, Gongying Li, Feng Jia, Ying Wang, Chuanjun Zhuo, Gao Si, Jingjing Zhu, and Peiwei Shan. "Effect of Sex on Treatment Compliance and Brain Activity Alterations in Patients with Schizophrenia: A Pilot Study." Psychiatry and Clinical Psychopharmacology 30.3 (2020), 214-221. Print. doi:10.5455/PCP.20200223125521



APA (American Psychological Association) Style

Ji, F., Li, . R., Ma, . X., Wang, . L., Li, . G., Jia, . F., Wang, . Y., Zhuo, . C., Si, . G., Zhu, . J. & Shan, . P. (2020) Effect of Sex on Treatment Compliance and Brain Activity Alterations in Patients with Schizophrenia: A Pilot Study. Psychiatry and Clinical Psychopharmacology, 30 (3), 214-221. doi:10.5455/PCP.20200223125521