E-ISSN 2475-0581
 

Original Article 


Cognitive Improvements from Adjunct Therapy with Transcranial Magnetic Stimulation are Short-Lived In Patients with Remitted Bipolar Disorder

Ying Wang, Chuanxin Liu, Tao Fang, Xiaodong Lin, Deguo Jiang, Jingjing Zhu, Chunjun Zhuo, Jiaen Ye.

Abstract
Objectives: Repetitive transcranial magnetic stimulation (rTMS) has been used as an adjunct therapy to improve the cognitive abilities of patients with remitted bipolar disorder (BPD). This is accomplished through functional brain activity alterations. However, there is limited information about the duration and persistence of cognitive improvements. Investigate the long-term cognitive effects (four weeks) of adjunct treatment with rTMS in patients with remitted BPD.
Methods: Patients with remitted BDP were enrolled in the study. rTMS was used in patients for four weeks. Global functional connectivity density (gFCD) was used to assess the alterations in brain activity before and after rTMS. The MATRICS Consensus Cognitive Battery (MCCB) was used to evaluate the cognitive abilities of patients before and after rTMS.
Results: Compared to the baseline, cognitive improvements were detected in patients at the end of two weeks of treatment, as determined through increased MCCB scores. The gFCD increase was observed in the frontal cortex, inferior temporal lobe, and parietal lobe. However, the MCCB scores did not increase further in the third week of treatment and declined by four weeks post-treatment. Similarly, the increased gFCD values also declined to nearly baseline values by the fourth week after treatment.
Conclusions: High frequency rTMS can improve the cognitive abilities of patients with remitted BPD rapidly; however, the beneficial effects are short-lived and begin to disappear by three weeks after treatment. The brain activity alterations induced by rTMS also increased initially, followed by substantial declines, suggesting that desensitization or exhaustion may play a role. Further investigations are needed to determine the optimal method for maintaining long-term cognitive improvements in patients with remitted BPD.

Key words: bipolar disorder, transcranial magnetic stimulation, global functional connectivity, cognitive function, desensitization, exhaustion


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Ying Wang
Articles by Chuanxin Liu
Articles by Tao Fang
Articles by Xiaodong Lin
Articles by Deguo Jiang
Articles by Jingjing Zhu
Articles by Chunjun Zhuo
Articles by Jiaen Ye
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Wang Y, Liu C, Fang T, Lin X, Jiang D, Zhu J, Zhuo C, Ye J. Cognitive Improvements from Adjunct Therapy with Transcranial Magnetic Stimulation are Short-Lived In Patients with Remitted Bipolar Disorder. Psychiatry and Clinical Psychopharmacology - PCP. 2020; 30(4): 346-353. doi:10.5455/PCP.20200221124442


Web Style

Wang Y, Liu C, Fang T, Lin X, Jiang D, Zhu J, Zhuo C, Ye J. Cognitive Improvements from Adjunct Therapy with Transcranial Magnetic Stimulation are Short-Lived In Patients with Remitted Bipolar Disorder. http://www.psychiatryandclinicalpsychopharmacology.org/?mno=88361 [Access: December 28, 2020]. doi:10.5455/PCP.20200221124442


AMA (American Medical Association) Style

Wang Y, Liu C, Fang T, Lin X, Jiang D, Zhu J, Zhuo C, Ye J. Cognitive Improvements from Adjunct Therapy with Transcranial Magnetic Stimulation are Short-Lived In Patients with Remitted Bipolar Disorder. Psychiatry and Clinical Psychopharmacology - PCP. 2020; 30(4): 346-353. doi:10.5455/PCP.20200221124442



Vancouver/ICMJE Style

Wang Y, Liu C, Fang T, Lin X, Jiang D, Zhu J, Zhuo C, Ye J. Cognitive Improvements from Adjunct Therapy with Transcranial Magnetic Stimulation are Short-Lived In Patients with Remitted Bipolar Disorder. Psychiatry and Clinical Psychopharmacology - PCP. (2020), [cited December 28, 2020]; 30(4): 346-353. doi:10.5455/PCP.20200221124442



Harvard Style

Wang, Y., Liu, . C., Fang, . T., Lin, . X., Jiang, . D., Zhu, . J., Zhuo, . C. & Ye, . J. (2020) Cognitive Improvements from Adjunct Therapy with Transcranial Magnetic Stimulation are Short-Lived In Patients with Remitted Bipolar Disorder. Psychiatry and Clinical Psychopharmacology - PCP, 30 (4), 346-353. doi:10.5455/PCP.20200221124442



Turabian Style

Wang, Ying, Chuanxin Liu, Tao Fang, Xiaodong Lin, Deguo Jiang, Jingjing Zhu, Chunjun Zhuo, and Jiaen Ye. 2020. Cognitive Improvements from Adjunct Therapy with Transcranial Magnetic Stimulation are Short-Lived In Patients with Remitted Bipolar Disorder. Psychiatry and Clinical Psychopharmacology, 30 (4), 346-353. doi:10.5455/PCP.20200221124442



Chicago Style

Wang, Ying, Chuanxin Liu, Tao Fang, Xiaodong Lin, Deguo Jiang, Jingjing Zhu, Chunjun Zhuo, and Jiaen Ye. "Cognitive Improvements from Adjunct Therapy with Transcranial Magnetic Stimulation are Short-Lived In Patients with Remitted Bipolar Disorder." Psychiatry and Clinical Psychopharmacology 30 (2020), 346-353. doi:10.5455/PCP.20200221124442



MLA (The Modern Language Association) Style

Wang, Ying, Chuanxin Liu, Tao Fang, Xiaodong Lin, Deguo Jiang, Jingjing Zhu, Chunjun Zhuo, and Jiaen Ye. "Cognitive Improvements from Adjunct Therapy with Transcranial Magnetic Stimulation are Short-Lived In Patients with Remitted Bipolar Disorder." Psychiatry and Clinical Psychopharmacology 30.4 (2020), 346-353. Print. doi:10.5455/PCP.20200221124442



APA (American Psychological Association) Style

Wang, Y., Liu, . C., Fang, . T., Lin, . X., Jiang, . D., Zhu, . J., Zhuo, . C. & Ye, . J. (2020) Cognitive Improvements from Adjunct Therapy with Transcranial Magnetic Stimulation are Short-Lived In Patients with Remitted Bipolar Disorder. Psychiatry and Clinical Psychopharmacology, 30 (4), 346-353. doi:10.5455/PCP.20200221124442