E-ISSN 2475-0581
 

Original Article 


Retinal Nerve Fiber Layer Thickness in Opioid Abusers

Mehmet Emrah Karadere, Tayfun Sahin, Ebru Cobanoglu, Veysi Yildiz.

Abstract
Introduction: Opioids are addictive substances that have been shown to have neurotoxic effects on the brain. These neurotoxic effects may be associated with retinal nerve fiber layer (RNFL) thickness. This study aims to examine retinal neural fiber layer thickness by optical coherence tomography (OCT) among opioid addicts.
Method: Therefore, both eyes of the 45 participants who met the diagnosis of opioid addiction according to DSM-5 (age: 26.13±6.20 years) and 45 healthy controls (age: 28.87±9.04 years) were examined in seven quadrants (superior temporal, superior nasal, temporal, nasal, inferior temporal, inferior nasal quadrants and global RNFL thickness) with OCT.
Results: Mean RNFL thicknesses in any quadrant did not differ statistically significantly between the groups (p>0.05). Furthermore, there was no statistically significant correlation between the duration of substance use and RNFL thicknesses. There is a statistically significant inverse correlation that has been found between the daily amount of substance use (gr)and RNFL thicknesses in the right eye temporal inferior (r: -0,499) and temporal superior (r: -0,351) and left eye nasal inferior (r: -0,387) quadrants, whereas there was not any statistically significant correlation in other quadrants.
Discussion: This study suggests that RNFL thickness may be the same as healthy controls for several reasons in opioid addicts. It would be appropriate for this to be confirmed by broader studies and for its mechanism to be investigated.

Key words: Optic coherence tomography, opioid, heroin, retinal nerve fiber layer


 
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How to Cite this Article
Pubmed Style

Karadere ME, Sahin T, Cobanoglu E, Yildiz V. Retinal Nerve Fiber Layer Thickness in Opioid Abusers. Psychiatry and Clinical Psychopharmacology - PCP. 2020; 30(4): 369-373. doi:10.5455/PCP.20200702123911


Web Style

Karadere ME, Sahin T, Cobanoglu E, Yildiz V. Retinal Nerve Fiber Layer Thickness in Opioid Abusers. http://www.psychiatryandclinicalpsychopharmacology.org/?mno=118241 [Access: December 28, 2020]. doi:10.5455/PCP.20200702123911


AMA (American Medical Association) Style

Karadere ME, Sahin T, Cobanoglu E, Yildiz V. Retinal Nerve Fiber Layer Thickness in Opioid Abusers. Psychiatry and Clinical Psychopharmacology - PCP. 2020; 30(4): 369-373. doi:10.5455/PCP.20200702123911



Vancouver/ICMJE Style

Karadere ME, Sahin T, Cobanoglu E, Yildiz V. Retinal Nerve Fiber Layer Thickness in Opioid Abusers. Psychiatry and Clinical Psychopharmacology - PCP. (2020), [cited December 28, 2020]; 30(4): 369-373. doi:10.5455/PCP.20200702123911



Harvard Style

Karadere, M. E., Sahin, . T., Cobanoglu, . E. & Yildiz, . V. (2020) Retinal Nerve Fiber Layer Thickness in Opioid Abusers. Psychiatry and Clinical Psychopharmacology - PCP, 30 (4), 369-373. doi:10.5455/PCP.20200702123911



Turabian Style

Karadere, Mehmet Emrah, Tayfun Sahin, Ebru Cobanoglu, and Veysi Yildiz. 2020. Retinal Nerve Fiber Layer Thickness in Opioid Abusers. Psychiatry and Clinical Psychopharmacology, 30 (4), 369-373. doi:10.5455/PCP.20200702123911



Chicago Style

Karadere, Mehmet Emrah, Tayfun Sahin, Ebru Cobanoglu, and Veysi Yildiz. "Retinal Nerve Fiber Layer Thickness in Opioid Abusers." Psychiatry and Clinical Psychopharmacology 30 (2020), 369-373. doi:10.5455/PCP.20200702123911



MLA (The Modern Language Association) Style

Karadere, Mehmet Emrah, Tayfun Sahin, Ebru Cobanoglu, and Veysi Yildiz. "Retinal Nerve Fiber Layer Thickness in Opioid Abusers." Psychiatry and Clinical Psychopharmacology 30.4 (2020), 369-373. Print. doi:10.5455/PCP.20200702123911



APA (American Psychological Association) Style

Karadere, M. E., Sahin, . T., Cobanoglu, . E. & Yildiz, . V. (2020) Retinal Nerve Fiber Layer Thickness in Opioid Abusers. Psychiatry and Clinical Psychopharmacology, 30 (4), 369-373. doi:10.5455/PCP.20200702123911