E-ISSN 2475-0581
 

Original Article 


Evaluation Serum Levels of G Protein-Coupled Estrogen Receptor and Its Diagnostic Value in Patients With Schizophrenia

Onur Hursitoglu, Fatma Ozlem Orhan, Ergul Belge Kurutas, Adem Doganer, Huseyin Toygun Durmuş, Ozlem Bozkus.

Abstract
Introduction: Estrogens not only play a role in the reproductive system of the female but also have a significant role in modulating the activities of serotonin, dopamine, glutamate and GABA, important neurotransmitters involved in schizophrenia. The physiological effects of estrogen-related components are mostly regulated by Estrogen receptor alpha (Erα), Estrogen receptor beta (Erβ), and G Protein-Coupled Estrogen Receptor (GPER-1) which are subtypes of estrogen receptors. The aim of this study was to examine the possible role of GPER-1 in schizophrenia by comparing schizophrenia patients with sex- and age-matched healthy controls and examining the association between symptom severity and GPER-1.
Methods: The study sample consisted of 36 people with schizophrenia and 30 age- and sex-matched healthy control subjects. Demographic and clinical characteristics were recorded by pre-designed questionnaires for participants, and all required laboratory tests and physical examinations were performed; the Positive and Negative Syndrome Scale (PANSS) was administered to all schizophrenia patients.
Results: We found that male schizophrenia patients had higher GPER-1 levels than male controls. However, we found no difference in the levels of GPER-1 between female patients and female controls. No significant correlation was found among age, PANSS score, duration of illness, and GPER-1 levels

Key words: sex hormones, GPER-1, estrogen receptor, schizophrenia, estradiol, sex differences, Diagnostic


 
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How to Cite this Article
Pubmed Style

OH, Orhan FO, Kurutas EB, Doganer A, Durmus HT, Bozkus O. Evaluation Serum Levels of G Protein-Coupled Estrogen Receptor and Its Diagnostic Value in Patients With Schizophrenia.


Web Style

OH, Orhan FO, Kurutas EB, Doganer A, Durmus HT, Bozkus O. Evaluation Serum Levels of G Protein-Coupled Estrogen Receptor and Its Diagnostic Value in Patients With Schizophrenia. http://www.psychiatryandclinicalpsychopharmacology.org/?mno=87040 [Access: June 08, 2020].


AMA (American Medical Association) Style

OH, Orhan FO, Kurutas EB, Doganer A, Durmus HT, Bozkus O. Evaluation Serum Levels of G Protein-Coupled Estrogen Receptor and Its Diagnostic Value in Patients With Schizophrenia.



Vancouver/ICMJE Style

OH, Orhan FO, Kurutas EB, Doganer A, Durmus HT, Bozkus O. Evaluation Serum Levels of G Protein-Coupled Estrogen Receptor and Its Diagnostic Value in Patients With Schizophrenia.



Harvard Style

, O. H., Orhan, . F. O., Kurutas, . E. B., Doganer, . A., Durmus, . H. T. & Bozkus, . O. (2020) Evaluation Serum Levels of G Protein-Coupled Estrogen Receptor and Its Diagnostic Value in Patients With Schizophrenia.



Turabian Style

, Onur Hursitoglu, Fatma Ozlem Orhan, Ergul Belge Kurutas, Adem Doganer, Huseyin Toygun Durmus, and Ozlem Bozkus. 2020. Evaluation Serum Levels of G Protein-Coupled Estrogen Receptor and Its Diagnostic Value in Patients With Schizophrenia.



Chicago Style

, Onur Hursitoglu, Fatma Ozlem Orhan, Ergul Belge Kurutas, Adem Doganer, Huseyin Toygun Durmus, and Ozlem Bozkus. "Evaluation Serum Levels of G Protein-Coupled Estrogen Receptor and Its Diagnostic Value in Patients With Schizophrenia."



MLA (The Modern Language Association) Style

, Onur Hursitoglu, Fatma Ozlem Orhan, Ergul Belge Kurutas, Adem Doganer, Huseyin Toygun Durmus, and Ozlem Bozkus. "Evaluation Serum Levels of G Protein-Coupled Estrogen Receptor and Its Diagnostic Value in Patients With Schizophrenia."



APA (American Psychological Association) Style

, O. H., Orhan, . F. O., Kurutas, . E. B., Doganer, . A., Durmus, . H. T. & Bozkus, . O. (2020) Evaluation Serum Levels of G Protein-Coupled Estrogen Receptor and Its Diagnostic Value in Patients With Schizophrenia.